Clearance of persistent hepatitis B virus infection in chinese bone marrow transplant recipients whose donors were anti-hepatitis B core- and anti-hepatitis B surface antibody-positive

摘要

Thirteen hepatitis B surface antigen-positive Chinese patients who received hepatitis B surface antibody-positive marrow (hepatitis B core antibody-positive or -negative: 6 and 7, respectively) via allogeneic bone marrow transplantation (BMT) were studied. After BMT, 4 recipients had serologic clearance of hepatitis B surface antigen from hepatitis B 'core antibody-positive marrow, but none of the recipients of hepatitis B core antibody-negative marrow had serologic clearance (P = .02). There was no significant difference in the donors' hepatitis B surface antibody triter before BMT for patients with or without serologic clearance of hepatitis B surface antigen (2255.2 ± 4244.0 vs. 854.2 ± 2306.7 mIU/mL; P = not significant). Adoptive immunity clearance of hepatitis B surface antigen was favored by hepatitis B core antibody positive-donor marrow and was not related to donor pre-BMT hepatitis B surface antibody titer.